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definición - Dexfenfluramine

Dexfenfluramine (n.)

1.(MeSH)The S-isomer of FENFLURAMINE. It is a serotonin agonist and is used as an anorectic. Unlike fenfluramine, it does not possess any catecholamine agonist activity.

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definición de Dexfenfluramine (Wikipedia)

sinónimos - Dexfenfluramine

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diccionario analógico

 

Ethylamines[Hyper.]

Dexfenfluramine (n.) [MeSH]


Wikipedia

Dexfenfluramine

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Dexfenfluramine
Systematic (IUPAC) name
(S)-N-Ethyl-1-[3-(trifluoromethyl)phenyl]-propan-2-amine
Identifiers
CAS number3239-44-9
ATC codeA08AA04
PubChem66265
DrugBankAPRD00648
ChemSpider59646
Chemical data
FormulaC12H16F3N 
Mol. mass231.257 g/mol
SMILESeMolecules & PubChem
Pharmacokinetic data
Bioavailability ?
Protein binding36%
Metabolism ?
Half life17-20 hours
Excretion ?
Therapeutic considerations
Pregnancy cat. ?
Legal statusSchedule IV (US) Withdrawn from market
Routes ?
 Y(what is this?)  (verify)

Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. It was for some years in the mid-1990s approved by the United States Food and Drug Administration for the purposes of weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn. After it was removed in the US, dexfenfluramine was also pulled out in other global markets. It was later superseded by sibutramine, which is a safer alternative to both dexfenfluramine and fenfluramine.

The drug was manufactured by Interneuron Pharmaceuticals and marketed by Wyeth-Ayerst Laboratories. It is the enantiomer of levofenfluramine.

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