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alemán árabe búlgaro checo chino coreano croata danés eslovaco esloveno español estonio farsi finlandés francés griego hebreo hindù húngaro indonesio inglés islandés italiano japonés letón lituano malgache neerlandés noruego polaco portugués rumano ruso serbio sueco tailandès turco vietnamita

definición - HOXD8

definición de HOXD8 (Wikipedia)

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HOXD8

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Homeobox D8
Identifiers
SymbolsHOXD8; HOX4; HOX4E; HOX5.4
External IDsOMIM142985 MGI96209 HomoloGene10473 GeneCards: HOXD8 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez323415437
EnsemblENSG00000175879ENSMUSG00000027102
UniProtP13378Q9CUH8
RefSeq (mRNA)XM_001132822XM_355338
RefSeq (protein)XP_001132822XP_355338
Location (UCSC)Chr 2:
176.7 - 176.7 Mb
Chr 2:
74.51 - 74.51 Mb
PubMed search[1][2]

Homeobox protein Hox-D8 is a protein that in humans is encoded by the HOXD8 gene.[1][2][3]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function.[3]

References

  1. ^ McAlpine PJ, Shows TB (Aug 1990). [Expression error: Missing operand for > "Nomenclature for human homeobox genes"]. Genomics 7 (3): 460. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). [Expression error: Missing operand for > "Vertebrate homeobox gene nomenclature"]. Cell 71 (4): 551–3. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXD8 homeobox D8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3234. 

Further reading

  • Goodman FR (2003). [Expression error: Missing operand for > "Limb malformations and the human HOX genes."]. Am. J. Med. Genet. 112 (3): 256–65. doi:10.1002/ajmg.10776. PMID 12357469. 
  • Redline RW, Williams AJ, Patterson P, Collins T (1992). [Expression error: Missing operand for > "Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts."]. Genomics 13 (2): 425–30. doi:10.1016/0888-7543(92)90263-R. PMID 1351871. 
  • Oliver G, Sidell N, Fiske W, et al. (1989). [Expression error: Missing operand for > "Complementary homeo protein gradients in developing limb buds."]. Genes Dev. 3 (5): 641–50. doi:10.1101/gad.3.5.641. PMID 2568311. 
  • Manohar CF, Salwen HR, Furtado MR, Cohn SL (1996). [Expression error: Missing operand for > "Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation."]. Tumour Biol. 17 (1): 34–47. doi:10.1159/000217965. PMID 7501971. 
  • Guazzi S, Lonigro R, Pintonello L, et al. (1994). [Expression error: Missing operand for > "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins."]. EMBO J. 13 (14): 3339–47. PMID 7913891. 
  • Rosen DR, Brown RH (1993). [Expression error: Missing operand for > "Dinucleotide repeat polymorphism in the HOX4E locus."]. Hum. Mol. Genet. 2 (5): 617. doi:10.1093/hmg/2.5.617. PMID 8100165. 
  • Del Campo M, Jones MC, Veraksa AN, et al. (1999). [Expression error: Missing operand for > "Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster."]. Am. J. Hum. Genet. 65 (1): 104–10. doi:10.1086/302467. PMID 10364522. 
  • Limongi MZ, Pelliccia F, Gaddini L, Rocchi A (2000). [Expression error: Missing operand for > "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1."]. Cytogenet. Cell Genet. 90 (1-2): 151–3. doi:10.1159/000015651. PMID 11060466. 
  • Kosaki K, Kosaki R, Suzuki T, et al. (2002). [Expression error: Missing operand for > "Complete mutation analysis panel of the 39 human HOX genes."]. Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


 

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