» 
alemán árabe búlgaro checo chino coreano croata danés eslovaco esloveno español estonio farsi finlandés francés griego hebreo hindù húngaro indonesio inglés islandés italiano japonés letón lituano malgache neerlandés noruego polaco portugués rumano ruso serbio sueco tailandès turco vietnamita
alemán árabe búlgaro checo chino coreano croata danés eslovaco esloveno español estonio farsi finlandés francés griego hebreo hindù húngaro indonesio inglés islandés italiano japonés letón lituano malgache neerlandés noruego polaco portugués rumano ruso serbio sueco tailandès turco vietnamita

definición - KCNAB2

definición de KCNAB2 (Wikipedia)

   Publicidad ▼

Wikipedia

KCNAB2

From Wikipedia, the free encyclopedia

Jump to: navigation, search
edit
Potassium voltage-gated channel, shaker-related subfamily, beta member 2

PDB rendering based on 1exb.
Available structures
1exb, 1qrq, 1zsx, 2a79
Identifiers
SymbolsKCNAB2; AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2; KCNA2B; KV-BETA-2; MGC117289
External IDsOMIM601142 MGI109239 HomoloGene56492 GeneCards: KCNAB2 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez851416498
EnsemblENSG00000069424ENSMUSG00000028931
UniProtQ13303Q3U0B0
RefSeq (mRNA)NM_003636NM_010598
RefSeq (protein)NP_003627NP_034728
Location (UCSC)Chr 1:
5.97 - 6.08 Mb
Chr 4:
151.23 - 151.32 Mb
PubMed search[1][2]

Voltage-gated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNAB2 gene.[1][2]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.[2]

In melanocytic cells KCNAB2 gene expression may be regulated by MITF[3].

Contents

See also

Interactions

KCNAB2 has been shown to interact with KCNA2.[4][5]

References

  1. ^ Schultz D, Litt M, Smith L, Thayer M, McCormack K (Mar 1997). [Expression error: Missing operand for > "Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B"]. Genomics 31 (3): 389–91. doi:10.1006/geno.1996.0065. PMID 8838324. 
  2. ^ a b "Entrez Gene: KCNAB2 potassium voltage-gated channel, shaker-related subfamily, beta member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8514. 
  3. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). [Expression error: Missing operand for > "Novel MITF targets identified using a two-step DNA microarray strategy"]. Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  4. ^ Coleman, S K; Newcombe J, Pryke J, Dolly J O (Aug. 1999). [Expression error: Missing operand for > "Subunit composition of Kv1 channels in human CNS"]. J. Neurochem. (UNITED STATES) 73 (2): 849–58. ISSN 0022-3042. PMID 10428084. 
  5. ^ Nakahira, K; Shi G, Rhodes K J, Trimmer J S (Mar. 1996). [Expression error: Missing operand for > "Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits"]. J. Biol. Chem. (UNITED STATES) 271 (12): 7084–9. ISSN 0021-9258. PMID 8636142. 

Further reading

  • McCormack K, McCormack T, Tanouye M, et al. (1995). [Expression error: Missing operand for > "Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product."]. FEBS Lett. 370 (1-2): 32–6. doi:10.1016/0014-5793(95)00785-8. PMID 7649300. 
  • McCormack T, McCormack K (1995). [Expression error: Missing operand for > "Shaker K+ channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily."]. Cell 79 (7): 1133–5. doi:10.1016/0092-8674(94)90004-3. PMID 8001150. 
  • Nakahira K, Shi G, Rhodes KJ, Trimmer JS (1996). [Expression error: Missing operand for > "Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits."]. J. Biol. Chem. 271 (12): 7084–9. doi:10.1074/jbc.271.12.7084. PMID 8636142. 
  • Kääb S, Dixon J, Duc J, et al. (1998). [Expression error: Missing operand for > "Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density."]. Circulation 98 (14): 1383–93. PMID 9760292. 
  • Coleman SK, Newcombe J, Pryke J, Dolly JO (1999). [Expression error: Missing operand for > "Subunit composition of Kv1 channels in human CNS."]. J. Neurochem. 73 (2): 849–58. doi:10.1046/j.1471-4159.1999.0730849.x. PMID 10428084. 
  • Poliak S, Gollan L, Martinez R, et al. (2000). [Expression error: Missing operand for > "Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels."]. Neuron 24 (4): 1037–47. doi:10.1016/S0896-6273(00)81049-1. PMID 10624965. 
  • Croci C, Brändstatter JH, Enz R (2003). [Expression error: Missing operand for > "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2."]. J. Biol. Chem. 278 (8): 6128–35. doi:10.1074/jbc.M205162200. PMID 12431995. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gu C, Jan YN, Jan LY (2003). [Expression error: Missing operand for > "A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels."]. Science 301 (5633): 646–9. doi:10.1126/science.1086998. PMID 12893943. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). [Expression error: Missing operand for > "Complete sequencing and characterization of 21,243 full-length human cDNAs."]. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). [Expression error: Missing operand for > "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."]. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rush J, Moritz A, Lee KA, et al. (2005). [Expression error: Missing operand for > "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."]. Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). [Expression error: Missing operand for > "The DNA sequence and biological annotation of human chromosome 1."]. Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
  • Lim J, Hao T, Shaw C, et al. (2006). [Expression error: Missing operand for > "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration."]. Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

 

todas las traducciones de KCNAB2


Contenido de sensagent

  • definiciones
  • sinónimos
  • antónimos
  • enciclopedia

  • definition
  • synonym

   Publicidad ▼

Investigaciones anteriores en el diccionario :

3915 visitantes en línea

computado en 0,124s

   Publicidad ▼

   Publicidad ▼