Ohmefentanyl (β-hydroxy-3-methylfentanyl) is an extremely potent analgesic drug which selectively binds to the µ-opioid receptor.
Ohmefentanyl is one of the most potent μ-receptor agonists known, comparable to super-potent opioids such as carfentanil and etorphine which are used for tranquilizing large animals such as elephants in veterinary medicine. In mouse studies, the most active isomer 3R,4S,βS-ohmefentanyl was 28 times more powerful as a painkiller than fentanyl, the chemical from which it is derived, and 6300 times more effective than morphine.. Ohmefentanyl has three stereogenic centers and so has eight stereoisomers, which are named F9201-F9208. Researchers are studying the different pharmaceutical properties of these isomers..
The 4"-fluoro analogue of the 3R,4S,βS isomer of ohmefentanyl is the most potent opioid yet discovered, possessing an analgesic potency approximately 18,000-fold greater than morphine.
Molecular structure of four ohmefentanyl isomers
- ↑ Guo, GW; He; Jin; Zou; Zhu; Chi (2000). [Expression error: Missing operand for > "Comparison of physical dependence of ohmefentanyl stereoisomers in mice"]. Life sciences 67 (2): 113–20. PMID 10901279.
- ↑ Liu, Z.; He, Y.; Jin, W.; Chen, X.; Shen, Q.; Chi, Z. (2004). [Expression error: Missing operand for > "Effect of chronic treatment of ohmefentanyl stereoisomers on cyclic AMP formation in Sf9 insect cells expressing human mu-opioid receptors"]. Life sciences 74 (24): 3001–3008. doi:10.1016/j.lfs.2003.10.027. PMID 15051423.
- ↑ Yong, Z; Hao; Weifang; Qiyuan; Xinjian; Wenqiao; Youcheng (2003). [Expression error: Missing operand for > "Synthesis and analgesic activity of stereoisomers of cis-fluoro-ohmefentanyl"]. Die Pharmazie 58 (5): 300–2. PMID 12779044.